Our laboratory mission is based on the scientific framework that disease occurs when the immune system fails. This is critical for the development of infection, cancer and autoimmunity. Our lab has two global research aims:
Determine how antibody immune responses are regulated.
Develop tools to engineer immunity.
We are studying antibody responses during pregnancy and after delivery to design strategies to improve infant immunity and protection from infection.
We are studying mechanisms of treatment resistance in lymphoma and developing novel therapeutic strategies to treat therapy-resistant tumors. Moreover, we are using gene expression within tumors to develop predictive models of risk during current treatment to better identify patients that would benefit from experimental therapies.
We are working to isolate and characterize the antibody response after SAR-CoV-2 infection in order to better predict disease and generate novel therapeutic and diagnostic tools.
Single-cell transcriptome analysis of over 100,000 immune cells from neonatal and adult blood.
Single-cell genomics
Our lab utilizes single-cell genomics tools to study the immune system at high-resolution and depth. This allows us to study information from thousands of individual cells and populations simultaneously providing a better understanding of the landscape of cells and the cellular microenvironment.
Multidimensional seromics to define immune health and disease
We perform multiple immune measures of both soluble and cell-based parameters to define immune cell health and identify changes in immunity that correlates with disease.