We seek to understand how immune responses are regulated and to develop tools to engineer immunity

Disease happens when the immune system fails. Dysregulation of the immune system can result in an over-stimulated immune response as observed in allergy and autoimmune disorders, or a poor immune response that results in susceptibility to infection and cancer. We are using genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and determine how human genetics impacts an individual immunity. We are using this information to identify biomarkers and pathways that can be targeted to improve immunotherapies and vaccines.